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doi: 10.3389/fimmu.2019.00239 174

Normal growth and development in the absence of hepatic insulin-like growth factor I

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analog of the immunomodulatory peptide tuftsin, in which a Pro-Gly-Pro motif has been appended at the C-terminus to improve metabolic stability

Notably, This type of Treg cell co-expressing Foxp3 and RORt (Th17-like Tregs) has been identified in humans and mice ( in vivo remain subjects of ongoing debate
