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Pitolisant's efficacy could be mediated through its activity that increases the synthesis and release of histamine in the brain via competitive binding to presynaptic histamine-3 autoreceptors

After ensuring optimal RNA quantity and quality, cDNA synthesis was performed using a commercial kit (ParsTous, Iran)

Thymosin alpha-1 and cancer: action on immune effector and tumor target cells

In addition, GABA can regulate macrophages and microglia, inhibit the activation of related inflammatory pathways such as the NF-B signaling pathway and reduce the release of inflammatory factors, thus inhibiting neuroinflammation and playing a neuroprotective role [12,13]

5 , a008656 (2013)