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SUMOs actually a natural thing Your cells use SUMO attachment (SUMOylation) as a way to flag proteins for things like transport to different parts of the cell In eukaryotic cells (most things except bacteria), SUMO can be added naturally as a POST-TRANSLATIONAL modification this means that the instructions for it are NOT in the gene for the protein

J Trauma 52:11411146 Morrison CA, Carrick MM, Norman MA, Scott BG, Welsh FJ, Tsai P, Liscum KR, Wall MJ Jr, Mattox KL (2011) Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial

Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase

Instruct patients to seek medical attention if they experience severe symptoms