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Pharmacological validation of inhibitor screening AlphaLISA using known inhibitors of the p53-MDM2 interaction HTS assays developed for drug discovery should be validated for pharmacological relevance and for assay performance

4.3.2 Parkinsons disease Oxidative stress has also been linked to the degeneration of dopaminergic neurons in Parkinsons Disease (PD) (Dias et al., 2013)

Thus, patients were given oral doses of 600 mg/day of VIC and 1500 mg/day divided over three doses for 10 days

10.1016/j.neurobiolaging.2016.08.019 69 CekanaviciuteE.YooB