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Research Articles on Glutathione Peroxidase 4 (GPX4)

Oxidative stress is crucial in atherogenesis (144151), suggesting that a specific antioxidant/prooxidant imbalance, characterized by a weak GSH-related enzymatic antioxidant shield present in human atherosclerotic lesions, may be involved in atherogenic processes in humans (152)

Frontiers in Endocrinology, 12 , 767785

showed that supraphysiological testosterone can inhibit tumor proliferation by producing lipid peroxides, targeting prostate cancer cell associated lipid metabolism to inhibit prostate cancer cell growth is considered as a possible therapeutic strategy [60]