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The ethanol-inducible form of P450 2E1 has been recognized as one of the prevailing mechanisms responsible for the generation of superoxide anion from ethanol and subsequent ethanol-induced lipid peroxidation.30,31 with a major involvement of GSH depletion.32 P450 2E1 has a very efficient NADPH oxidase activity which generates substantial amount of superoxide anion and H2O2 as well as hydroxyethyl radicals, all likely to be responsible for ethanol induction of oxidative stress and lipid peroxidation