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The rationality of implementation of dimethyl sulfoxide as differentiation-inducing agent in cancer therapy

Circumstantial evidence for this hypothesis comes from one cohort study in which the combination of low B12 and high folate status was associated with lower serum holotranscobalamin concentrations than when B12 was low but folate was not elevated (81)

Obesity is a predominantly pro-inflammatory process, and the main mechanism is that in obesity, classically activated macrophages (M1) have higher concentrations than alternatively activated macrophages (M2), expressing pro-inflammatory cytokines, and activating pro-inflammatory pathways, such as the JNK and TNF-kB signaling pathways, which lead to low-grade chronic inflammation throughout the body (190)

16 , e2003782 (2018)

doi: 10.1097/00005392-200009010-00064