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In this context, the neuroprotective impact of protocatechuic acid on chemobrain caused by cyclophosphamide has been recently evaluated [29]
A subsequent French trial with 20 SARS-CoV-2 patients suggested that hydroxychloroquine treatment (at 600 mg daily) significantly reduced viral load [100]
These observations led to phase 2 clinical trial, which evaluated the effects of trilaciclib administered prior to etoposide and carboplatin for treatment of small cell lung cancer
