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Critics will ask: Why design REDEFINE-4 as an open-label trial

investigators who additionally want the KPV anti-inflammatory tripeptide use the four-component KLOW Blend

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clEDS is caused by homozygous or compound heterozygous pathogenic variants in the TNXB gene, which leads to nonsense-mediated mRNA decay of TNXB and result in complete absence of TN-X or in misfolding of the protein8

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