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Therapeutic effect evaluation Twenty tumor-bearing female BALB/c mice, each aged 5 weeks, were randomly assigned into four groups, with each group comprising five mice

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TOX/TOX2 and NR4A13 function as central regulators that cooperate to establish and maintain an exhaustion program through chromatin remodeling and epigenetic stabilization ( Mechanistically, mitochondrial stress provides a plausible bridge between these states