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Several medications can interact with vitamin B12 or affect its absorption, including: Metformin (diabetes medication) Proton pump inhibitors and H2-receptor antagonists (acid-reducing medications) Specific antibiotics (neomycin, chloramphenicol) Colchicine (gout medication) Aminosalicylic acid Nitrous oxide (inactivates vitamin B12) Allergic reactions to vitamin B12 are extremely uncommon but can occur