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LIP: labile iron pool

Nrf2 is a transcription factor that regulates the expression of antioxidants and anti-inflammatory genes

Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial

The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies