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Brief Pain Inventory Short Form (BPI-SF) 24-h average pain score (item 5) 4 at the screening and baseline visits

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Common reactions include: Temporary soreness or redness at the injection site, which typically resolves within a few hours

Unlike peptides that require brain penetration, klotho enhances cognition when administered peripherallydespite not crossing the blood-brain barriersuggesting it acts through systemic signaling mechanisms that remain incompletely understood