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Several studies suggested that vitamin B-12 status in women in resource-limited countries is poor

Body composition in DIO mice with/without NNMT inhibition showing reduced WAT mass with preserved lean mass relative to diet-matched controls [1,3,4]

Discussion The major findings of our study are that advanced age is associated with impaired NVC responses in humans and that age-related decreases of circulating IGF-1 levels predict the magnitude of age-related decline in functional hyperemia

For example, a study published in the Journal of Alternative and Complementary Medicine found that B12 supplements improved endurance and reduced fatigue in athletes

Patients with Leber's Disease: Vitamin B12 levels may exacerbate optic nerve atrophy