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It appears that excess oxidative stress causes posttranslational modification of Nrf2

Each bottle provides 60 count veggie capsules (30 servings) SUGGESTED CAPSULE USE: Take 2 capsules daily preferably on an empty stomach, or as recommended by a nutritionally informed physician

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doi: 10.3810/pgm.2014.01.2730

In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41