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In the altered scenario of cholestasis, the retention of more hydrophobic bile salts, such as the glyco- and tauro-conjugates of deoxycholate, plays a major part in the onset of liver injury, causing hepatotoxicity due to mitochondrial dysfunction and production of ROS, with consequent oxidative damage [181,182]

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Emo possesses anti-inflammatory and immunomodulatory effects, and simultaneously exhibits a certain degree of activity in blood glucose regulation [243]

By shaping redox tone, iron availability, lipid composition, and cytokine output, macrophage metabolic states critically influence ferroptotic susceptibility in adjacent cancer cells and define their overall contribution to tumor development

These foam cells are generated through the phagocytosis of significant lipid quantities by MCs [76]