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As the immune system targets the thyroid gland, it causes inflammation and interferes with hormone synthesis and release

Borthakur G, Duvvuri S, Tsao T, Zhang W, Ruvolo V, Lu H, Kojima K, Konopleva M, Andreeff M

in lungs as compared to the free drug

Since then, methotrexate, arguably the most recognized antifolate, has been employed in the treatment of various neoplastic and inflammatory conditions [28]
