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This led to the development of compounds irreversibly interacting with EGFRm/T790M, such as afatinib, 324674 and more recently AZD9291 and CO1696 [1012]

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Nervous System MNPs are increasingly recognized for their neurotoxic potential due to their ability to cross biological barriers, accumulate in regions such as the hippocampus and cortex, and impair central nervous system function

[PMC free article: PMC2659363] [PubMed: 18937674] 876

J Altern Complement Med 23(4):249258 Chinna Meyyappan A, Forth E, Wallace CJK, Milev R (2020) Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review