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It is possible that the blood lactate levels were lower because of the secondary role of L-carnitine balancing the acetyl-CoA/CoA ratio allowing pyruvate to be converted into acetyl-CoA instead of lactate (31), but this is unlikely due to the moderate intensity level when blood lactate was evaluated

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Recent studies have highlighted the protective role of AX on skeletal muscle subjected to metabolic stress induced by high-fat diets (HFD) or accumulation of fatty acids such as palmitate

Thus, NHR-49 acts as an important modulator balancing lipid consumption and storage, likely in response to varying energy needs