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Subsequent clinical investigation confirmed that acute ischemic stroke patients had higher plasma 5-oxoproline and GSH levels than age- and sex-matched non-stroke controls

Its -glutamyl linkage provides structural stability against typical peptidases, while the free thiol group makes it sensitive to oxidation, requiring storage under inert atmospheres

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Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous Cushing's disease or non-functioning pituitary adenoma

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