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doi: 10.1093/rheumatology/keac069 133 WuJFengZChenLLiYBianHGengJet al

294 Cellular and animal experiments have found that long-chain fatty acids cause excessive oxidation of adipocytes, producing inflammatory cytokines, facilitating macrophage infiltration, and leading to systemic low-grade inflammation

Yadav S, Gattacceca F, Panicucci R, Amiji MM

Globally, these findings point to an important role of various forms of autophagy in the regulation of ferroptosis

Direct preclinical evidence has primarily implicated AKG in the regulation of synaptic plasticity and autophagy-related pathways
