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One complicating factor is that different kava products were used in these trials

Sci Rep 7(1):3255

Their "integrated trigger point hypothesis" describes an energy crisis at the motor endplate (the junction where nerve meets muscle)

Mushrooms are a rich source of two powerful antioxidantsglutathione and ergothioneinewhich help shield cells from damage and support immune function, said Laszlo

Regul Toxicol Pharmacol 153:105709
