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Although this adaptive change temporarily maintains energy supply, it can lead to long-term mitochondrial bioenergetic dysfunction and reduced OXPHOS efficiency, thereby affecting the energy metabolic homeostasis of distant organs via the circulatory system

On the other hand, senomorphic drugs modulate SASP and suppress secretory potential without eliminating senescent cells [76]

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Intestines Interestingly, by using a mouse model of intestinal IRI, it was shown that protein levels of GPX4 were decreased at early timepoints after reperfusion, whereas the expression of PTGS2 was increased and treatment with liproxstatin-1 attenuated the decrease in GPX4 expression and reduced cyclooxygenase-2 expression