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Furthermore, elevated UA levels are associated with endothelial dysfunction, vascular injury and remodeling, and increased inflammatory responses [128], and the protective effects of UA can be masked when it exceeds a certain level

Biochim Biophys Acta 1852(3):451461
PHGDH, phosphoglycerate dehydrogenase

This is local discomfort, not a sign the treatment has gone wrong
Contraception 1987
