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Langmuir Am Chem Soc (2025) 41:2428194

7.5.3 Methodological differences The diverse methodologies employed in studies, including variations in sampling techniques, analytical methods, and experimental designs, can lead to disparate findings

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Because IGF-1 is normally found at low levels in MetS and T2D, maybe because of insulin cessation to inhibit IGFBP-1 production by the liver and because of decreased liver IGF-1 secretion by insulin stimulation, as insulin resistance prevails in the liver