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The subcutaneous implant prepared by POE and norethisterone (NET) was pharmacologically studied in baboons and showed that serum levels reached a steady state within 2 days after insertion and remained relatively stable for 5 months [49]

However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment

Compounded medications are prepared at the direction of a healthcare provider and are not approved by the FDA

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