l carnitine inj 500 mg ml L- 500mg/ml Injectable injectable l carnitine 500 mg/ml

Because of its presence in the skin, several studies have found that lutein and zeaxanthin may offer protection against light-induced damage, especially from UV light 12

In addition to its GLT1 modulating effect (Rothstein et al., 2005), ceftriaxone has been studied extensively for its neuroprotective activity

In parallel, these improvements may decrease the peripheral leptin levels, reducing the effects of leptin resistance, promoting a peripheral synergic thermogenic effect with adiponectin (Fig

4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage

The translational implications of these findings were explored through preclinical testing of combination therapy targeting both AKT1 and copper metabolism