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2017) and abolishes metastatic potential of squamous cancer cells by inhibition of a non-receptor tyrosine kinase, Src, and pro-metastatic Signal transducer and activator of transcription 3 (STAT3) transcription factor (Fan et al

The preference for the product glycan rather than the substrate raises the possibility that the lectin domain is involved in either prompt product release during the catalytic reaction cycle or the efficient modification of glycoproteins in which 1-4GlcNAc already exists (Fig

For instance, under certain experimental conditions or in specific cell types, their relationship exhibits an inverse association

Zhu L, Han B, Wang L, Chang Y, Ren W, Gu Y, et al