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Tamion F, Richard V, Renet S, Thuillez C (2006) Protective effects of heme-oxygenase expression against endotoxic shock: inhibition of tumor necrosis factor-alpha and augmentation of interleukin-10

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In obese subjects, overpopulated immune cells (mainly macrophages) and dysfunctional adipocytes secrete a variety of cytokines and chemokines, causing low-grade long-term inflammation in AT, which plays a determining role in metabolic diseases, such as cardiovascular diseases, liver steatosis and type 2 diabetes [2]