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Consistent daily dosing maintains steady beta-3 adrenergic receptor stimulation and produces better cumulative results than intermittent dosing

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Contraindications include Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera

Standard dosing approach The most commonly cited dosing range is 50 to 150mg per day, typically divided into one to three doses

Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall