gout glutathione In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour Diseases Linked to LOW GLUTATHIONE

Tang J, Ramis-Cabrer D, Wang X, Barreiro E

(high GSH consumption for regeneration of other redox systems, such as e.g.Ascorbic acid Effects of glutathione Antioxidant effects Non-enzymatic antioxidant Most important hydrophilic antioxidant of the cell (directly binds radicals and nitric oxide (NO) and reduces other antioxidants) It is oxidized to GSSG (and reduced again with the help of the enzyme glutathione reductase) Coenzyme for enzymatic glutathione peroxidases (metalloenzymes) (reduce toxic peroxides such as hydrogen peroxide and lipid hydroperoxides by reacting with glutathione) Enzymes are proteins (they require amino acids, zinc, vitamin B6 and B12) Enzymes require activators (selenium, zinc, manganese) Regeneration of antioxidants Inactivation of activated oxygen Detoxifying effects of GSH Glutathione in detoxification phase I Disposal of radical metabolites (Part of the redox network) Glutathione in detoxification phases II and III Coenzyme for glutathione S-transferases Binding partners of pollutants begins via thiol/sulfhydryl/SH group Toxins, polyvalent heavy metals such as mercury, cadmium, lead and other foreign substances forms Pollutant-glutathione complexes , which are excreted as mercapturic acid derivatives via the kidneys and bile reduces by Complex formation with "good" trace elements pro-oxidative risk of high concentrations of these substances (z.B

Mol Biol Rep 48:23352350 Rajput SA, Wang X-q, Yan H-C (2021) Morin hydrate: a comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential

10.1002/jcb.28901

Thus, it suggested that the radioprotective activity of DHS was due to its ability to elevate cellular GPx activity levels which probably inhibited the radiation-induced G/M arrest or mitotic death by augmenting DNA repair