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Moreover, one included trial directly demonstrated biochemical changes consistent with this mechanism: children with ASD who responded to methyl-B 12 injections exhibited normalization of their methylation indices, including an increase in the S-adenosylmethionine to S-adenosylhomocysteine (SAM/SAH) ratio [25]

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Trial and label protocols hold the current step when nausea, vomiting, constipation, reflux, or food aversion has not settled