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They help with conditions like gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome

Evaluate dosage considerations : For high-dose supplements, taking them on an empty stomach may be beneficial due to increased passive absorption

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And here's where it get difficult again...there are many types of anaemia (not just macrocytic or iron anaemia) so pinning the anaemia down to just those causes (especially if those potential causes are being treated) might be a reductive approach - especially as you still have symptoms which could be due to anaemia

Methotrexate and its mechanisms of action in inflammatory arthritis