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Description
spontaneous NADPH oxidation

In addition, the same study also showed that the treatment of erastin (an inducer of iron toxicity) decreased GPX4 and ferritin levels in human epidermal melanocytes (HEMs) while increasing TfR and Acyl-CoA synthetase long-chain family member 4 (ACSL4) expression, indicating that HEMs are sensitive to ferroptosis (97)
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Biochem Pharmacol 77 (1): 4653

In recent years, ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has gained significant attention in OA pathogenesis
