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As proteostasis capacity becomes constrained, newly synthesized polypeptides requiring high chaperone support for proper folding may become increasingly vulnerable, rendering neuronal cells more susceptible to damage
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Nature Communications, 14 , 7793
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia
Next, H 2 O 2 (100 L of 30 M in labeling buffer) was added and fluorescence measurements were acquired in triplicate
