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This study pioneered an in vivo self-assembly strategy to develop a PKM2 allosteric converter, dually suppressing the Warburg effect and chemoresistance in renal cell carcinoma (RCC) through an enzyme-responsive self-assembly and sustained activation mechanism

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It is crucial to understand that reclassified does not mean FDA-approved. Compounded peptides are not FDA-approved drugs, but they are now legally accessible for physicians to prescribe when deemed medically appropriate for a patient

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This provides an example of how Nrf2 can influence other cellular processes indirectly, through the regulation of redox homeostasis