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Since sleep regulates the brains clearance of metabolic toxins such as tau and A-42 peptides via the glymphatic system, age-related sleep disruption may impair this clearance, thereby exacerbating neuronal pathology through increased ROS production and ultimately triggering neuronal apoptosis (Xie et al., 2013

This study aimed to clarify the molecular and biochemical changes in the hippocampus induced by SAE through multi-omics integration (proteomics and metabolomics), thereby providing a theoretical basis for improved neuroprotective strategies

Unlike many other antioxidants that we must consume through food, your body actually produces its own supply of glutathione within the liver