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The antagonism of acetylcholine can lead to adverse reactions such as cognitive impairment, confusion, blurred vision, hallucinations, urinary retention, and constipation

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In cerebral malaria, there is a low availability of NO and low plasma concentrations of L-arginine, a substrate for NO synthesis (Lopansri et al., 2003), and hypoargininemia has been strongly associated with mortality (Alkaitis et al., 2016

doi: 10.1038/bcj.2015.58 54 FengXFilippini VelzquezGBohlscheidSUnterfraunerMAnandPRejeskiHAet al