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To counteract ERS, cells initiate the UPR via three major pathwaysPERK, inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)to coordinate adaptive repair and death decisions [206]

PLoS ONE 14(4): e0215815

As a consequence of the complex pathomechanisms and difficulty in treatment, COPD is among the leading causes of mortality both in the western countries and in the developing world