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Description
The search for biased ligands, however, is not without an inherent set of difficulties
For example, RHEB1 upregulation, which increases mTORC1 activity, leads to worse median survival in acute myeloid leukemia patients
Compared to the latter, irreversible or mechanism-based inhibition is of longer duration due to the formation of strong covalent bonds and is dependent on the formation of inhibitor metabolites
Obara Y, Imai T, Sato H, Takeda Y, Kato T, Ishii K
Unfortunately, a kidney biopsy is not always feasible for various reasons, especially in the acute setting
