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Description
An earlier LEGEND Hypertension study, published in The Lancet, found that thiazide diuretics were more effective and caused fewer side effects than ACE inhibitors when used as first-line antihypertensive drugs

Gclc w/f or Gclc w/w mice (Gclc WT) and Gclc f/f mice (hereafter referred to as Gclc L-KO) were monitored following tail-vein injection with AAV-TBG-Cre (Fig

doi:10.1016/j.clinthera.2023.12.010

Cell Rep (2018) 25:20619.e4

It is hypothesized to be linked to excessive MMP-1 activity, which could temporarily break down existing collagen faster than new collagen is built
