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It skews immune balance away from Tregs toward Th17 polarization, reducing immune regulation while enhancing auto-reactivity and mucosal vulnerability

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1, there are mainly three isoforms of SODs including cytoplasmic Cu/Zn SOD (SOD1), mitochondrial Mn SOD (SOD2) and extracellular Cu/Zn SOD (SOD3 or EcSOD)

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