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Ironsulfur cluster biogenesis genes implicated in human diseases Human disease mutations have now been reported for Frataxin , GLRX5 and ISCU (Figure 2)
The SARS-CoV-2-induced FeRD, its ensuing OxS could deplete cellular antioxidant reserves and increase severity of COVID-19 and PASC 27

However, it should be remarked that not all exposed workers are necessarily susceptible, demonstrating the crucial role of the genetic background of each individual in the appearance of the disease

Alston CL, et al