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Rodents cannot produce mature -MSH due to the lack of a di-basic cleavage site [31], although -MSH has higher affinity at both the human MC4R and the rat MC4R when compared to -MSH (30- and 4-fold, respectively) [61]

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S2), suggesting that the plasma level alterations of POMC in this genetic background are mainly due to the decrease in melanocytic e/e Pomc production caused by loss of Mc1r function

doi: 10.1371/journal.pone.0057855 60 MaJLiuCYangYYuJYangJYuSet al