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under ferroptotic conditions, lysosomal leakage releases hydrolytic enzymes and iron-rich contents into the cytosol, amplifying oxidative stress (72)

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MRP-1 has been implicated in the etiology of a wide array of human pathologies, including inflammatory bowel disease, cystic fibrosis, Alzheimers disease, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression 10,11,12,13,14,15,16,17