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However, translational challenges persist, including the lack of pharmacokinetic standardization between oral and intravenous routes, tumor-type-specific response heterogeneity, and incomplete understanding of VCs immunomodulatory dynamics

FAHFA belong to the lipid class referred to as estolides which are intermolecular esters of fatty acids

Ann Intern Med 125:384389 [DOI] [PubMed] [Google Scholar] Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL (2013) The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation