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This study focuses on an unexplored area of PD pathogenesis by characterizing the interplay between astrocytes, inflammation and BBB integrity, and by combining patient-derived induced pluripotent stem cells with microfluidic technologies to generate a 3D human BBB chip

Pattern across both trials Nausea, vomiting, and diarrhea peaked during dose escalation and tapered during maintenance

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167,168 A double-blind controlled trial enrolled 55 older women with type 2 diabetes and randomized them to receive either 200 mg pyridoxamine twice daily or placebo for one year

Both Sensenbrenner et al