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In this case, ROS act as signaling molecules that regulate tumor metabolism in response to changes in the cellular environment

Funding This study was supported by grants from the Japan Society for the Promotion of Science (20H00509, 20H05876, and JPJSBP 120207405 to KH), AMED-Crest (20gm1010004h0105 and 20gm1310009h0001 and to KH), and The Naito Foundation (KH)

S20, we confirm in cultured BRL-3A rat hepatocytes that treatment with erastin causes accumulation of cellular NO and ROS/lipid-ROS in a concentration- and time-dependent manner, and their accumulation followed a sequential order, i.e

[DOI] [PubMed] [Google Scholar] 315.Majak P., Olszowiec-Chlebna M., Smejda K., Stelmach I

This effectively protects limbs from ischemia-reperfusion-induced mitochondrial damage, preserves mitochondrial energy metabolism, and prevents excessive ATP consumption (Fu et al., 2019)