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Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function

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However, LVF triple therapy is not recommended as a first-line choice for most patients because resistance to LVF is increasing worldwide, but in areas of low LVF resistance and high CLR and MTZ resistance or unavailability of bismuth, this therapy can be used (OMorain et al

The finding of low plasma sulfate is also consistent with a large study that found high sulfate in the urine of children with autism [41], as sulfate wasting in the urine partly explains low levels in the plasma