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Blocking the transmission of the HGF/c-MET pathway in CAFs has been demonstrated to impede the movement of CRC cells driven by RAB31 expression, highlighting the role of CAFs in enhancing paracrine HGF release and stimulating the HGF/c-MET pathway, which in turn propels tumor growth [48]

doi: 10.1007/s11368-015-1101-y 26 FinckS

Antibodies can directly bind to a region of a pathogen or toxin that is used for cellular entry ( Figure 1B )

doi: 10.1371/journal.pone.0028386 159 YangYWuHYangYKangYHeRZhouBet al

The small molecule inhibitor 6877002 targeting the CD40-TRAF6 pathway alters human inflammatory monocytes, resulting in reduced production of ROS, TNF, and IL-6, while increasing the production of IL-10